Every infusion at Mind Spa is designed to be a full sensory experience. We use immersive sound vibration to guide the experience, a clinical team monitoring your vitals throughout the entire treatment, and AI-generated art to capture the experience. For adults with treatment-resistant depression, PTSD, and anxiety.
IV ketamine is used off-label. Read the FDA information.
Every ketamine infusion at Mind Spa is built inside three layers at the same time, designed to support comfort and reflection from the moment the infusion starts to the moment it ends.
A curated visual experience, designed to give you something to focus on and reflect on during the session.
Low-frequency sound delivered as vibration you feel through your body as well as hear, designed to promote a sense of calm.
Trained clinical staff track your blood pressure and other vitals for the whole infusion, and can slow or pause it at any point.
Here is how a ketamine visit at Mind Spa runs. Your provider tailors the details to you.
A licensed psychiatric provider completes a full evaluation and screens for conditions that can make ketamine unsafe. No infusion is scheduled until that is done.
Staff check your vitals and place a small IV line.
A low dose of ketamine runs at a controlled rate, with the vibroacoustic therapy experience running alongside it. A temporary dreamlike or detached feeling, called dissociation, is common. Staff monitor you the entire time.
The infusion ends, effects usually fade soon after, and staff check on you before you leave.
Someone else drives you home. No driving until the next day.
The standard initial series is 6 infusions. Your provider decides with you whether follow-up infusions make sense.
Here is what IV ketamine is, what it is not, and how Mind Spa keeps it safe.
Ketamine acts on glutamate, the brain's most common signaling chemical, by blocking NMDA receptors (N-methyl-D-aspartate receptors, one of the receptor types glutamate acts on). This is a different mechanism from standard antidepressants.
Research associates ketamine with increased brain-derived neurotrophic factor (BDNF), a protein involved in synaptic plasticity, the brain's ability to strengthen or weaken connections between nerve cells. Some patients notice changes sooner than with oral antidepressants. Others take longer or do not respond.
| Treatment | FDA status |
|---|---|
| IV ketamine (Mind Spa) | FDA-approved as an anesthetic. Used off-label for depression, PTSD, and anxiety. |
| Esketamine (Spravato) nasal spray | FDA-approved in 2019 for treatment-resistant depression, and later for depressive symptoms with acute suicidal thoughts or behavior. |
Your provider will review the evidence, risks, and alternatives with you.
IV ketamine may be worth discussing with a provider if you are an adult and:
Randomized trials have studied IV ketamine for treatment-resistant depression and chronic PTSD.
Studied a single ketamine infusion in adults with treatment-resistant depression and reported faster symptom improvement than placebo.
Zarate et al., Archives of General Psychiatry (opens the study in a new tab)Compared ketamine with midazolam, an active placebo, and reported a higher response rate with ketamine at 24 hours.
Murrough et al., American Journal of Psychiatry (opens the study in a new tab)Reviewed evidence and safety practices for ketamine in mood disorders, including patient screening and monitoring.
Sanacora et al., JAMA Psychiatry (opens the study in a new tab)Studied six ketamine infusions over two weeks against midazolam in chronic PTSD and reported greater symptom reduction with ketamine.
Feder et al., American Journal of Psychiatry (opens the study in a new tab)Infusions use sub-anesthetic doses, far below the doses used for surgery. Common side effects during or shortly after an infusion include:
Effects usually fade soon after the session. You cannot drive until the next day, so plan a ride home.
Your provider screens for conditions that can make ketamine unsafe or inappropriate, including:
Inner Armor is our 7 to 12 week outpatient program for TRICARE Prime, Select, and Reserve Select beneficiaries. It combines 36 TMS sessions, 6 ketamine infusions, and 36 HBOT sessions, plus medication management and therapy as needed. Standard TRICARE copays and cost-shares apply, and we review your expected costs with you before you begin.
Mind Spa is an independent clinic in network with TRICARE West and is not affiliated with or endorsed by TRICARE, the Defense Health Agency, or the Department of Veterans Affairs.
IV ketamine for mental health is generally not covered by insurance as a standalone treatment, because it is used off-label. Current ketamine pricing is on our insurance and cost page, and we review every cost with you before treatment begins.
Colorado EMS professionals and their families can ask about Path4EMS, a grant program that covers $250 per ketamine session, up to $1,250 per family per year.
Every infusion at Mind Spa is delivered as an immersive experience. Vibroacoustic therapy delivers low-frequency sound as vibration you feel through your body, and an immersive AI-generated art experience gives you something to focus on and reflect on. Both are designed to support comfort and reflection, and trained clinical staff monitor your vitals throughout.
No. IV ketamine is FDA-approved as an anesthetic and is used off-label for depression, PTSD, and anxiety. The only FDA-approved ketamine-based treatment for depression is esketamine (Spravato) nasal spray, for treatment-resistant depression and for depressive symptoms with acute suicidal thoughts or behavior. Your provider will review the evidence, risks, and alternatives with you.
Spravato is esketamine, a related form of ketamine, given as a nasal spray under FDA-approved rules. IV ketamine is given through a vein at a controlled rate and is used off-label. Mind Spa offers IV ketamine infusions.
Each infusion lasts 60 to 90 minutes. Trained clinical staff monitor your vitals throughout. Mind Spa pairs every infusion with vibroacoustic therapy, which uses low-frequency sound vibration, and an immersive AI-generated art experience, both designed to support comfort and reflection. You need a ride home afterward.
The standard initial series at Mind Spa is 6 infusions over 2 to 3 weeks. Your provider decides with you whether follow-up infusions make sense based on your response.
The most common side effects are lightheadedness, dizziness, nausea, dissociation (a temporary feeling of detachment), and a temporary rise in blood pressure. Staff can give anti-nausea medication, pause the infusion, or adjust the rate. Effects usually fade soon after the session.
Ketamine has been used in hospital anesthesia for decades. At Mind Spa, infusions use sub-anesthetic doses with continuous monitoring, and your provider screens you before treatment to confirm ketamine is appropriate for you.
No. Plan for someone to drive you home, and do not drive until the next day.
IV ketamine for mental health is generally not covered as a standalone treatment because it is used off-label. Eligible TRICARE beneficiaries can ask about Inner Armor, and Colorado EMS professionals and their families can ask about Path4EMS. We review all costs with you before treatment begins.
Some patients notice changes within days, and others take longer or do not respond. Your provider tracks your progress with you. Individual results vary and are not guaranteed.
Bring a full list of your medications to your evaluation. Your provider reviews them and tells you what to continue, since some medications can affect how ketamine works.
Complete the new patient paperwork or call 303-327-0350. A licensed psychiatric provider completes a full evaluation before any infusion is scheduled.
Peer-reviewed sources and official notices for the information on this page. Studies of IV ketamine for depression, PTSD, and anxiety describe off-label uses.
Start your new patient paperwork or call our team. A licensed psychiatric provider reviews your history before any infusion is scheduled.
Mind Spa, 5340 S. Quebec St., Suite 230S, Greenwood Village, CO 80111. Open Monday to Friday, 9am to 5pm. Mind Spa provides care to patients located in Colorado. Your first visit is in person at our Greenwood Village clinic, and some follow-up visits are available by telehealth.
IV ketamine is not FDA-approved for depression, PTSD, or anxiety and is used off-label. The only FDA-approved ketamine-based treatment for depression is esketamine (Spravato) nasal spray. Individual results vary and are not guaranteed.
All treatment at Mind Spa is subject to the medical decision-making of a licensed psychiatric provider. Mind Spa is not a crisis service. If you are in crisis, call or text 988. Veterans can dial 988 and press 1.
