Major Depressive Disorder (MDD) is a common but serious mental health condition that affects millions of people. It can interfere with daily life, relationships, and overall well-being. For some, traditional treatments aren’t effective, leading to a condition known as Treatment-Resistant Depression (TRD). This page explains the symptoms, diagnosis, and treatments for MDD and TRD, including innovative therapies like Transcranial Magnetic Stimulation (TMS) and ketamine infusion therapy.
MDD, often referred to as "clinical depression," goes beyond occasional sadness or feeling down. It’s a persistent mental health condition that disrupts daily life and requires medical attention.
The DSM-5 defines MDD as having at least five of the following symptoms for two weeks or longer. One of these must be either a depressed mood or a loss of interest in activities:
These symptoms must cause significant impairment in daily life to be considered MDD.
Treatment-Resistant Depression (TRD) occurs when someone with MDD does not respond to at least two different antidepressant medications taken at the proper dose and duration. For those with TRD, symptoms persist despite traditional treatments, leading to a greater impact on quality of life.
At Mind Spa, we specialize in advanced, evidence-based treatments for MDD and TRD. Our goal is to help patients find relief when traditional approaches don’t work.
TMS is a non-invasive treatment that uses magnetic pulses to stimulate areas of the brain involved in mood regulation. TMS is FDA-cleared for major depressive disorder in adults who have not responded to antidepressant medication. Individual results vary.
Benefits of TMS:
IV ketamine is used off-label for treatment-resistant depression. Administered via IV infusion. Research associates IV ketamine with rapid symptom improvement in some patients. Unlike traditional antidepressants, ketamine targets different pathways in the brain, making it a powerful option for those who have not exerpienced relief from traditional antidepressant medications.
Benefits of Ketamine Therapy:
We provide expert evaluation and management of antidepressants and other psychiatric medications to support each patient’s overall treatment plan.
Talk therapy is an essential part of treating Major Depressive Disorder (MDD) and Treatment-Resistant Depression (TRD). At Mind Spa, we incorporate evidence-based therapy methods to complement advanced treatments like Transcranial Magnetic Stimulation (TMS) and ketamine infusion therapy. One innovative therapeutic approach we offer is the Comprehensive Resource Model (CRM®), which is designed to address emotional trauma and chronic stress.
CRM® is a trauma-focused therapy approach designed to help individuals process deep emotional pain by connecting the brain's most primitive areas to its healthiest, most resilient aspects. This neuro-biologically informed therapy draws on internal resources, including:
Mind Spa uses the Apollo TMS Therapy System, which is FDA-cleared for major depressive disorder and OCD. IV ketamine is used off-label for depression and is not FDA-approved for this use. The only FDA-approved ketamine-based treatment for depression is esketamine (Spravato) nasal spray. Individual results vary and are not guaranteed. Mind Spa is not a crisis service. If you are in crisis, call or text 988. Veterans can dial 988 and press 1. Mind Spa is open Monday to Friday, 9am to 5pm, at 5340 S. Quebec St., Suite 230S, Greenwood Village, CO 80111.
